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Updated: Mar 9, 2026
Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging
Published on: June 21, 2011
Size-dependent lymphatic uptake of nanoscale-tailored particles as tumor mass increases
Pontus Kjellman1, Sarah Fredriksson2, Christian Kjellman3
1Medical Radiation Physics, Department of Clinical Sciences, Lund University, Barngatan 2:1, SE-22185, Lund, Sweden; GeccoDots AB, Lund, Sweden; Medical Radiation Physics, Department of Clinical Sciences, Lund University, Barngatan 2:1, SE-22185, Lund, Sweden; GeccoDots AB, Lund, Sweden.
Aim:
To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.
Materials & Methods:
Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged using MRI.
Results & Conclusion:
The larger of the two particles can only be detected in the lymph node when injected in animals with 6-day-old tumors while the 29 nm ultra-small superparamagnetic iron oxide nanoparticle is observed on both time points. Tumor mass greatly impacts the size of particles that are transported to the lymph nodes.
