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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
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Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Detailed Structure and Function of Lymph Nodes01:23

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
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Overview of the Vascular System01:20

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The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
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Lymphatic network in atherosclerosis: the underestimated path.

Andreea Milasan1, Jonathan Ledoux1, Catherine Martel1

  • 1Montreal Heart Institute, Research Center, Montreal, QC, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada; Montreal Heart Institute, Research Center, Montreal, QC, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Future Science OA
|December 30, 2016
PubMed
Summary
This summary is machine-generated.

The lymphatic system, crucial for fluid balance and immune cell transport, is increasingly recognized for its role in atherosclerosis. Recent advances illuminate lymphatic vessel function in this cardiovascular disease.

Keywords:
atherosclerosislymphatic endotheliumlymphatic smooth muscle cellslymphatic vessels

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Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Vascular Biology

Background:

  • The lymphatic vascular system maintains tissue fluid homeostasis and facilitates immune cell trafficking and cholesterol metabolism.
  • Historically understudied, lymphatic vessel dysfunction is linked to lymphedema, with emerging roles in other pathologies.
  • Recent discoveries in lymphatic development and imaging have spurred interest in its connection to atherosclerosis.

Approach:

  • This review synthesitsizes current knowledge on lymphatic vascular system interactions with atherosclerosis.
  • It provides a historical perspective on the research in this field.
  • Emphasis is placed on the physiological mechanisms governing the lymphatic system's role in disease onset and progression.

Key Points:

  • The lymphatic system's low-pressure, open network contrasts with the high-pressure blood vascular system.
  • Lymphatic vessels are critical for immune cell transport and cholesterol homeostasis.
  • Advances in genetic discoveries and imaging techniques have enabled deeper understanding of lymphatic function in atherosclerosis.

Conclusions:

  • The lymphatic vascular tree plays a multifaceted role in the development and progression of atherosclerosis.
  • Understanding these interactions is vital for novel therapeutic strategies.
  • Further research into lymphatic physiology is essential for cardiovascular health.