Related Experiment Video
Updated: Mar 9, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
Nanostructured lipid carriers: versatile oral delivery vehicle
Neelam Poonia1, Rajeev Kharb2, Viney Lather3
1Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India; Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India.
Abstract:
Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therapeutic functionality and prolonged release from these carrier systems thus providing improved pharmacokinetic parameters. The present review provides an overview of noteworthy studies reporting impending benefits of NLCs in oral delivery and highlights recent advancements for developing engineered NLCs either by conjugating polymers over their surface or modifying their charge to overcome the mucosal barrier of GI tract for active transport across intestinal membrane.
Related Concept Videos
Oral Drug Delivery Systems: Introduction
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Oral Drug Delivery Systems: Delayed-Release Systems
Bioavailability Enhancement: Drug Permeability Enhancement
Oral Drug Delivery Systems: Continuous-Release Systems
Drug Delivery Systems: Different Types

