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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
10.2K
Nanostructured lipid carriers: versatile oral delivery vehicle
Neelam Poonia1, Rajeev Kharb2, Viney Lather3
1Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India; Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India.
Future Science OA
|December 30, 2016
Summary
Nanostructured lipid carriers (NLCs) improve oral drug delivery for poorly soluble compounds. Engineered NLCs overcome gastrointestinal barriers, enhancing bioavailability and therapeutic outcomes.
Area of Science:
- Drug Delivery
- Nanotechnology
- Pharmacokinetics
Background:
- Oral drug delivery is preferred for its cost-effectiveness and convenience.
- Poor solubility and permeability of many drugs limit their oral bioavailability.
- Nanostructured lipid carriers (NLCs) offer a promising solution for enhancing drug delivery.
Approach:
- This review examines studies on NLCs for oral drug delivery.
- It highlights advancements in engineering NLCs to improve drug absorption.
- Strategies include polymer conjugation and surface charge modification.
Key Points:
- NLCs enhance the therapeutic functionality of incorporated bioactives.
- They provide sustained release, improving pharmacokinetic profiles.
- Engineered NLCs facilitate active transport across the intestinal mucosal barrier.
Conclusions:
- NLCs represent a significant advancement in overcoming challenges in oral drug delivery.
- Further development of engineered NLCs holds potential for improved therapeutic efficacy.
- This technology can enhance the delivery of poorly soluble and permeable drugs.
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