Direct Assembly of Prenylated Heteroarenes through a Cascade Minisci Reaction/Dehydration Sequence
Dong-Hang Tan1, Yao-Fu Zeng1, Yao Liu1
1School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 P. R. China.
Abstract:
The prenyl group is an important component in bioactive compounds. Herein, we report the assembly of prenylated heteroarenes through a cascade Minisci reaction and acid-promoted dehydration sequence. The use of potassium (3-hydroxy-3-methylbut-1-yl)trifluoroborate as a new coupling reagent allows the direct introduction of prenyl and 3-hydroxy-3-methylbutyl groups to a wide variety of electron-deficient heteroarenes. Synthetic application is also demonstrated.
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