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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Perinatal suicidal ideation and behaviour: psychiatry and adversity
Michael Nnachebe Onah1, Sally Field2, Jason Bantjes3
1Perinatal Mental Health Project, Alan J. Flisher Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, 46 Sawkins Road, Building B, Rondebosch, Cape Town, 7700, South Africa. chebis.onah@gmail.com.
Suicidal ideation and behaviors (SIB) affect 18% of pregnant women in South Africa. Risk factors include low socioeconomic status and interpersonal violence, not just depression.
Area of Science:
- Perinatal mental health
- Global public health
- Psychiatry
Background:
- Pregnant women face higher risks of suicidal ideation and behaviors (SIB).
- Research often overlooks contextual risk factors, especially in low- and middle-income countries.
- South African pregnant women in low-resource settings are a vulnerable population.
Purpose of the Study:
- To determine the prevalence of SIB among pregnant women in South Africa.
- To identify associated psychiatric and socio-economic contextual risk factors for SIB.
- To highlight the need for suicide risk assessment independent of depression and anxiety.
Main Methods:
- A cross-sectional study involving 376 pregnant women in low-resource South African communities.
- Data collection included socio-economic, demographic, social support, life events, interpersonal violence, and mental health diagnoses.
- Statistical analyses included univariate, bivariate, and logistic regression.
Main Results:
- The 1-month prevalence of SIB was 18%.
- SIB was linked to major depressive episode and anxiety disorders, but a significant proportion had no such diagnoses.
- Key risk factors included lower socioeconomic status, food insecurity, interpersonal violence, multiparity, and prior suicide attempts.
Conclusions:
- Socio-economic and contextual factors significantly contribute to SIB in pregnant women.
- Suicide risk assessment should be conducted independently of depression and anxiety diagnoses.
- Interventions should address broader social determinants of mental health in perinatal populations.
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