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Updated: Mar 9, 2026

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
Published on: August 12, 2019
Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View
Lik Hang Yuen1, Raphael M Franzini1
1Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT, 84113, USA.
Abstract:
DNA-encoded chemical libraries (DECLs) are pools of DNA-tagged small molecules that enable facile screening and identification of bio-macromolecule binders. The successful development of DECLs has led to their increasingly important role in drug development, and screening hits have entered clinical trials. In this review, we summarize the development and currently active research areas of DECLs with a focus on contributions from groups at academic institutes. We further look at opportunities and future directions of DECL research in medicinal chemistry and chemical biology based on the symbiotic relationship between academia and industry. Challenges associated with the application of DECLs in academic drug discovery are further discussed.
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