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Updated: Mar 9, 2026
Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
Published on: May 8, 2015
A Programmable DNA Double-Write Material: Synergy of Photolithography and Self-Assembly Nanofabrication
Youngjun Song1, Tsukasa Takahashi1, Sejung Kim1
1Department of Electrical and Computer Engineering, ‡Department of Mechanical Engineering, §Department of Materials Science and Engineering, ∥Department of Nanoengineering, and ⊥Department of Bioengineering, University of California San Diego , La Jolla, California 92093-0448, United States.
Abstract:
We demonstrate a DNA double-write process that uses UV to pattern a uniquely designed DNA write material, which produces two distinct binding identities for hybridizing two different complementary DNA sequences. The process requires no modification to the DNA by chemical reagents and allows programmed DNA self-assembly and further UV patterning in the UV exposed and nonexposed areas. Multilayered DNA patterning with hybridization of fluorescently labeled complementary DNA sequences, biotin probe/fluorescent streptavidin complexes, and DNA patterns with 500 nm line widths were all demonstrated.
