Related Experiment Video
Updated: Mar 9, 2026
Formulation and Acoustic Modulation of Optically Vaporized Perfluorocarbon Nanodroplets
Published on: July 16, 2021
Polymer-Stabilized Perfluorobutane Nanodroplets for Ultrasound Imaging Agents
Yuran Huang1, Alexander M Vezeridis1, James Wang1
1Materials Science & Engineering Program, ‡Department of Radiology, and §Department of Chemistry & Biochemistry, University of California-San Diego , La Jolla, California 92093, United States.
Abstract:
In this paper, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be cross-linked. After UV-induced thiol-ene cross-linking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound.
