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Related Concept Videos

Increased pulse rate01:17

Increased pulse rate

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Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
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Decreased pulse rate01:14

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Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
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Pulse rhythm01:30

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Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
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Holter Monitor: 24-Hour Monitoring01:23

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Holter monitoring is a continuous electrocardiography (ECG) recording that tracks the heart's electrical activity over an extended period, generally 24 to 48 hours. This noninvasive diagnostic tool detects irregular heart rhythms that may not be captured during a standard ECG performed in a clinical setting.DeviceThe Holter monitor is a portable, small device connected to several electrodes on the patient's chest. These electrodes detect the heart's electrical signals and transmit them to the...
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Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

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Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
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Actin filaments undergo polymerization and depolymerization from either end. The polymerization and depolymerization rates depend on the cytosolic concentration of free G-actins. The polymerization rate is generally higher at the plus or barbed end, while the depolymerization rate is higher at the minus or pointed end. At a steady state, critical concentration describes the concentration of free G-actin monomers at which the polymerization rate at the plus end is equal to that of the...
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Rescue left bundle branch area pacing in coronary venous lead failure or nonresponse to biventricular pacing: Results from International LBBAP Collaborative Study Group.

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Related Experiment Video

Updated: Mar 9, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Permanent His Bundle Pacing: The Past, Present, and Future.

Parikshit S Sharma1, Kenneth A Ellenbogen2, Richard G Trohman1

  • 1Division of Cardiology, Rush University Medical Center, Chicago, IL, USA.

Journal of Cardiovascular Electrophysiology
|December 30, 2016
PubMed
Summary
This summary is machine-generated.

Long-term right ventricular apical pacing risks heart failure and death. His bundle pacing offers a potential alternative, improving cardiac resynchronization therapy outcomes.

Keywords:
bundle branch block (BBB)cardiac resynchronizationclinical outcomespermanent His bundle pacing (HBP)

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Area of Science:

  • Electrophysiology
  • Cardiology
  • Medical Devices

Background:

  • Long-term right ventricular (RV) apical pacing is linked to adverse outcomes, including heart failure and atrial fibrillation (AF).
  • Conventional cardiac resynchronization therapy (CRT) using biventricular (BiV) leads has limitations, with a significant nonresponse rate (25-30%) and reduced efficacy in specific patient subgroups.
  • Alternative pacing sites have not surpassed RV apical pacing in efficacy.

Observation:

  • The His bundle (HB) region has emerged as a feasible and potentially advantageous pacing site.
  • Recent research highlights the feasibility and benefits of permanent His bundle pacing.
  • Understanding the anatomy and physiology of the HB is crucial for its application.

Findings:

  • Permanent His bundle pacing demonstrates feasibility and potential advantages over traditional pacing methods.
  • His bundle pacing may offer improved outcomes in patients undergoing cardiac resynchronization therapy.
  • The review consolidates current data on His bundle pacing techniques and outcomes.

Implications:

  • His bundle pacing represents a promising alternative to RV apical pacing and may enhance CRT efficacy.
  • Further research into His bundle pacing could refine treatment strategies for heart failure and conduction abnormalities.
  • This approach may broaden the application of His bundle pacing in clinical practice.