Related Experiment Video
Updated: Mar 9, 2026
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
Incremental Value of 18F-Fluorocholine PET/CT in the Localization of Double Parathyroid Adenomas
Paul Lalire1, Sang Ly, Sophie Deguelte
1From the *Unité thyroïde, Institut Jean Godinot, Reims; †Service d'endocrinologie, diabétologie, nutrition, ‡Service de chirurgie digestive et endocrinienne, and §Laboratoire d'anatomie et cytologie pathologique, Hôpital Robert Debré, CHU de Reims; ∥Service de médecine nucléaire, Institut Jean Godinot, Reims; ¶Laboratoire de Biophysique, UFR de médecine, Université de Reims Champagne Ardenne; and **CRESTIC EA 3804, Université de Reims Champagne Ardenne.
Abstract:
A 73-year-old man displaying primary hyperparathyroidism with severe hypercalcemia (Ca: 4.1 mmol/l, PTH > 600 pmol/l) was referred for preoperative localization of a parathyroid adenoma. Tc-pertechnetate and Tc-sestaMIBI dual tracer scintigraphy displayed a mild focal uptake in the projection of the right thyroid lobe with negative ultrasonography. F-Fluorocholine PET/CT was quickly performed considering this discrepancy and not only confirmed the scintigraphic findings but also revealed a second contralateral focus of increased uptake, both later confirmed by operative consideration (the two other parathyroid glands are considered normal by the surgeon), pathology, and intraoperative parathyroid hormone assessment.
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