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Correlation of baseline hormonal disorders with immunological failure and mortality in male HIV patients during

Ying Wen1, Hai Bo Ding, Wei Chen

  • 1Department of Infectious Diseases, The First Affiliated Hospital Department of Laboratory Medicine, Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou Shenyang Chest Hospital, Shenyang, Liaoning Province, China.

Medicine
|December 30, 2016
PubMed

Insights

Hormonal imbalances, particularly high cortisol, significantly impact HIV prognosis in men. These disturbances are linked to increased mortality and disease progression, highlighting the need for endocrine monitoring in HIV care.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Immunology

Background:

  • Hormonal disturbances can influence disease outcomes.
  • Understanding these effects in HIV-positive individuals is crucial for prognosis.

Purpose of the Study:

  • To investigate the impact of pre-antiretroviral therapy (ART) hormone levels on HIV prognosis in male patients.
  • To identify hormone-related predictors of immunological failure and mortality.

Main Methods:

  • Prospective follow-up study of 163 male HIV patients initiating ART.
  • Analysis of pre-ART hormone levels, CD4+ T cell counts, and clinical stage.
  • Kaplan-Meier method and multivariate Cox proportional hazard models were employed.

Main Results:

  • Mortality rate was 16.0%, with 84.6% of deaths being AIDS-related.
  • 53 patients experienced immunological failure.
  • High cortisol levels, hyponatremia, tuberculosis, and WHO stage 4 significantly associated with mortality.
  • WHO stage 4 also associated with immunological failure.
  • Dehydroepiandrosterone sulfate levels correlated with CD4+ counts and clinical stage.

Conclusions:

  • High cortisol levels are a significant predictor of mortality in male HIV patients.
  • While hormonal factors influence mortality, they showed no strong correlation with immunological failure in this cohort.
  • Endocrine assessment may be valuable for predicting HIV prognosis.

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