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Related Experiment Video

Updated: Mar 9, 2026

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[Kidneys in diffuse systemic sclerosis].

Małgorzata Dębowska1, Monika Staszków2

  • 1Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska, mdebowsk@gmail.com.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|December 30, 2016
PubMed
Summary

Systemic scleroderma can cause kidney problems, including the serious scleroderma renal crisis. This review covers the causes, symptoms, and treatments for this severe complication.

Keywords:
hypertensionsclerodermal renal crisissystemic sclerodermascleroderma

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Area of Science:

  • Rheumatology
  • Nephrology
  • Autoimmune Diseases

Background:

  • Systemic scleroderma is a chronic autoimmune connective tissue disease affecting skin, joints, and internal organs.
  • Renal involvement occurs in 60-80% of diffuse scleroderma cases.
  • Scleroderma renal crisis (SRC) is a severe complication affecting 5-20% of patients.

Purpose of the Study:

  • To review the pathogenesis, risk factors, symptoms, and treatment of scleroderma renal crisis.
  • To highlight SRC as a critical complication of systemic scleroderma.

Main Methods:

  • Literature review of pathogenesis, risk factors, clinical manifestations, and treatment strategies for SRC.
  • Synthesis of current knowledge on SRC within the context of systemic scleroderma.

Main Results:

  • SRC presents with severe hypertension, acute kidney injury (oliguria, proteinuria, erythrocyturia), and microangiopathic hemolytic anemia with thrombocytopenia.
  • Risk factors and specific pathogenic mechanisms are discussed.
  • Current treatment approaches are reviewed.

Conclusions:

  • Scleroderma renal crisis is a life-threatening complication requiring prompt recognition and management.
  • Understanding pathogenesis and risk factors is crucial for early detection and intervention.
  • Multidisciplinary management is essential for improving outcomes in patients with SRC.