A new phenol glycoside from Physalis angulata.

Area of Science:

• Natural Products Chemistry
• Pharmacology

Background:

• Physalis angulata is a plant species known for its diverse phytochemical constituents.
• Phenol glycosides represent a class of natural compounds with potential biological activities.

Purpose of the Study:

• To isolate and characterize novel and known compounds from Physalis angulata.
• To evaluate the inhibitory activity of isolated compounds on nitric oxide (NO) production.

Main Methods:

• Phytochemical investigation using spectroscopic techniques (NMR, IR, UV, HRESIMS).
• Isolation of compounds through chromatographic methods.
• Assay of nitric oxide production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.

Main Results:

• A new phenol glycoside, physanguloside A (1), was identified.
• Four known compounds (2-5) were isolated, with compounds 2-5 reported for the first time in the genus Physalis.
• The inhibitory activity of all isolated compounds on NO production was evaluated.

Conclusions:

• Physalis angulata is a source of novel and known phenol glycosides.
• The study provides preliminary data on the anti-inflammatory potential of these compounds by assessing their effect on nitric oxide production.