Benign Lymphoepithelial Lesion of the Parotid Gland in the Setting of HAART

The benign lymphoepithelial lesion is a rare and diagnostically challenging entity. Classically, these lesions present as early manifestation of HIV infection and are rarely seen in those on highly active antiretroviral therapy. We describe 2 rare cases of HIV-associated lympho-epithelial lesions of parotid gland in a 37-year-old female and a 47-year-old male receiving antiretroviral therapy. The lesions were characterized with respect to clinical features, as well as histopathology and radiology findings. Fine-needle aspiration cytology revealed benign squamous epithelium and lymphocytes. Sonographic evaluation of the parotid gland demonstrated intraparotid solid hypoechoic nodule. Computed tomography showed cystic and solid masses. These lesions were diagnosed as benign lymphoepithelial lesions in both cases. To our knowledge, this is the first report in the published literature describing newly occurring benign lymphoepithelial lesions in patients on antiretroviral therapy.