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Genomic sequencing and precision medicine in head and neck cancers

R C Hoesli1, M L Ludwig1, N L Michmerhuizen1

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|December 31, 2016
PubMed

Insights

Recent genetic sequencing studies are improving our understanding of head and neck squamous cell carcinoma (HNSCC). This knowledge is paving the way for targeted therapies to improve patient outcomes for this deadly cancer.

Area of Science:

  • Oncology
  • Genomics
  • Cancer Research

Background:

  • Head and neck squamous cell carcinoma (HNSCC) is a significant cause of cancer mortality.
  • Traditional treatments like surgery and chemoradiation offer limited success.
  • The genetic underpinnings of HNSCC have historically been poorly understood.

Purpose of the Study:

  • To review current knowledge and advances in HNSCC genetic sequencing.
  • To discuss limitations and future directions in genomic analysis for HNSCC.
  • To highlight translational research for novel HNSCC treatments.

Main Methods:

  • Review of recent next-generation sequencing studies in HNSCC.
  • Analysis of the genetic landscape of HNSCC.
  • Examination of translational research efforts.

Main Results:

  • Next-generation sequencing is revealing the genetic drivers of HNSCC.
  • Identification of potential targets for personalized medicine is increasing.
  • Genomic insights are beginning to inform treatment strategies.

Conclusions:

  • Advances in HNSCC genomic analysis are crucial for understanding disease progression.
  • Targeted therapies based on genetic profiles hold promise for improved patient outcomes.
  • Continued research integrating genomic data with clinical application is essential for combating HNSCC.
Keywords:
GenomicsHNSCCHead and neck cancerPersonalized medicinePrecision medicine

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