Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

4.0K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Motivational neurobehavioral abnormalities under a naturalistic goal-conflict task in patients with premenstrual dysphoric disorder.

Frontiers in psychiatry·2026
Same author

Prospective randomized trial of tumor-treating fields with chemoradiation in newly diagnosed glioblastoma.

Neuro-oncology advances·2026
Same author

Ethical considerations in randomization for neurosurgical oncology trials: A scoping review.

Neuro-oncology practice·2026
Same author

A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification.

Nature genetics·2026
Same author

Updated clinical practice guidelines for the management of adult diffuse gliomas.

Cancer letters·2025
Same author

Empathy training in healthcare: an umbrella review.

BMC medical education·2025

Related Experiment Video

Updated: Mar 9, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.6K

Surgery-Independent Language Function Decline in Patients Undergoing Awake Craniotomy.

Tal Gonen1, Gal Sela2, Ranin Yanakee2

  • 1Department of Neurosurgery, Tel-Aviv Medical Center, Tel Aviv, affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Functional Brain Center, Tel-Aviv Medical Center, Tel Aviv, affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; School of Psychological Sciences, Tel Aviv University, Tel-Aviv, Israel.

World Neurosurgery
|December 31, 2016
PubMed
Summary

Patients undergoing awake-craniotomy may experience a decline in language function after entering the operating room (OR). Tumor pathology and preoperative language deficits are key predictors of this decline, impacting patient selection.

Keywords:
Awake craniotomyCognitive reserveEloquent brain regionLanguageTumor

More Related Videos

Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping
09:16

Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping

Published on: March 24, 2023

2.1K
Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

13.6K

Related Experiment Videos

Last Updated: Mar 9, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.6K
Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping
09:16

Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping

Published on: March 24, 2023

2.1K
Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

13.6K

Area of Science:

  • Neurosurgery
  • Neuroscience
  • Cognitive Science

Background:

  • Awake-craniotomy requires language function monitoring.
  • Some patients experience unexpected language decline in the operating room (OR).
  • This decline can hinder functional monitoring during surgery.

Purpose of the Study:

  • To prospectively compare language function before surgery and upon entering the OR.
  • To identify factors associated with language decline in awake-craniotomy patients.

Main Methods:

  • Prospective evaluation of 79 patients undergoing awake-craniotomy for gliomas.
  • Language function assessed 1-2 days before surgery and on OR entry.
  • Analysis of demographic, clinical, and pathological characteristics influencing language changes.

Main Results:

  • A significant decline in language function was observed after entering the OR (P < 0.001).
  • Decline was associated with age, Karnofsky Performance Scale, tumor location, and pathology.
  • Tumor pathology and preoperative language deficits independently predicted functional decline.

Conclusions:

  • Patients may experience substantial language decline upon OR entry during awake-craniotomy.
  • Tumor grade and preoperative language deficits are significant risk factors.
  • Identifying at-risk patients may improve selection for awake-craniotomy and monitoring.