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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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Pharmaceutical Equivalents01:26

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As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
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Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Pharma partnering: other people's science.

Christian Hofmann1

  • 1Roche Partnering, F. Hoffmann-La Roche, South San Francisco, CA 94080 hofmann.christian@gene.com.

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Summary
This summary is machine-generated.

Pharmaceutical partnering helps identify and acquire external innovations for novel treatments. Advanced scientific training is crucial for evaluating these assets, guiding PhDs into business careers.

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Area of Science:

  • Pharmaceutical industry
  • Business development
  • Drug discovery

Background:

  • Transitioning from scientific research to business roles.
  • The importance of external innovation in pharmaceutical pipelines.

Purpose of the Study:

  • To explain the function of partnering in pharmaceutical companies.
  • To provide guidance for scientists transitioning to business careers.

Main Methods:

  • Describing the process of pharmaceutical partnering.
  • Offering advice for career transitions from PhD programs.

Main Results:

  • Partnering identifies and acquires external innovations.
  • Scientific expertise is vital for asset evaluation.

Conclusions:

  • Partnering is a key business discipline for scientists.
  • Successful transition requires understanding of external innovation acquisition.