Molecular Neuroimaging in Posttraumatic Stress Disorder
Jooyeon Jamie Im1, Eun Namgung2, Yejee Choi2
1Ewha Brain Institute, Ewha Womans University, Seoul 03760, Korea.; Interdisciplinary Program in Neuroscience, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
Experimental Neurobiology
|December 31, 2016
Summary
Molecular neuroimaging reveals altered brain metabolism and neurochemistry in posttraumatic stress disorder (PTSD). These findings in brain regions like the limbic cortex offer insights into PTSD neurobiology and treatment response.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Posttraumatic stress disorder (PTSD) is increasingly studied using neuroimaging.
- Molecular neuroimaging techniques are crucial for understanding metabolic and neurochemical changes in PTSD.
Approach:
- This review synthesizes findings from molecular neuroimaging studies in PTSD.
- Focuses on positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS).
Key Points:
- Patients with PTSD exhibit altered cerebral metabolism, perfusion, receptor binding, and metabolite profiles.
- Key affected brain regions include the limbic, medial prefrontal, and temporal cortices.
- Studies on brain correlates of treatment response in PTSD are also examined.
Conclusions:
- Molecular neuroimaging provides valuable insights into the neurobiological underpinnings of PTSD.
- Identifies specific alterations in brain function and chemistry associated with the disorder.
- Highlights limitations and future research directions in molecular neuroimaging for PTSD.
Keywords:
Magnetic resonance spectroscopy (MRS)Molecular neuroimagingPositron emission tomography (PET)Posttraumatic stress disorder (PTSD)Single photon emission computed tomography (SPECT)More Related Videos
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