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The therapeutic applications of antimicrobial peptides (AMPs): a patent review
Hee-Kyoung Kang1, Cheolmin Kim2, Chang Ho Seo2
1Department of Biomedical Sciences, Chosun University, Gwangju, 61452, Republic of Korea.
Abstract:
Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs.
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