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Extra-acral cutaneous sclerosing perineurioma with CD34 fingerprint pattern
Ricardo S Macarenco1, Jade Cury-Martins2
1Hospital Israelita Albert Einstein, Pathology Department and Instituto do Cancer do Estado de São Paulo (ICESP), Anatomic Pathology Division, São Paulo, Brazil.
Journal of Cutaneous Pathology
|December 31, 2016
Summary
Sclerosing perineuroma, a rare skin tumor, was found on the neck, an unusual location. This case showed a distinctive CD34 expression pattern, aiding in diagnosis.
Area of Science:
- Dermatopathology
- Oncology
- Immunohistochemistry
Background:
- Sclerosing perineuroma is an extraneural tumor typically found in acral (extremity) locations.
- While rare, perineuromas can occur in non-acral sites.
- CD34 expression in a fingerprint-like pattern has been noted in some perineuromas.
Observation:
- This report details a case of sclerosing perineuroma on the neck skin of a 56-year-old male.
- This represents a previously undocumented site for this specific neoplasm.
- The tumor exhibited CD34 expression in a fingerprint-like pattern.
Findings:
- The neck sclerosing perineuroma displayed a characteristic fingerprint-like CD34 immunolabeling.
- Alpha smooth-muscle actin showed a similar expression pattern, suggesting fibroblastic/myofibroblastic origin.
- Lesional cells were positive for epithelial membrane antigen and claudin1, but negative for S100, GLUT1, MUC4, and desmin.
Implications:
- This finding expands the known anatomical distribution of sclerosing perineuroma.
- The distinctive CD34 expression pattern can aid in the diagnosis of non-acral sclerosing perineuromas.
- Understanding the immunophenotype helps elucidate the cellular origin and potential diagnostic markers for this rare tumor.
