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Chronic kidney disease in neurogenic bladder.
Bong Mo Sung1, Dong-Jin Oh2, Moon Hee Choi3
1Department of Urology, Korea Workers' Compensation & Welfare Hospital, Incheon, South Korea.
Nephrology (Carlton, Vic.)
|December 31, 2016
Summary
Chronic kidney disease (CKD) is significantly more prevalent in neurogenic bladder (NB) patients than the general population. Serum Cystatin-C is a more reliable marker for detecting CKD in NB patients than serum creatinine.
Area of Science:
- Nephrology
- Urology
- Internal Medicine
Background:
- Neurogenic bladder (NB) is suspected to increase chronic kidney disease (CKD) risk, but data are limited.
- Serum creatinine (sCr) is unreliable for assessing renal function in NB patients due to muscle wasting.
- Serum Cystatin-C offers a more accurate assessment of kidney function in this population.
Purpose of the Study:
- To estimate CKD prevalence in NB patients using serum Cystatin-C.
- To identify risk factors associated with CKD development in NB patients.
Main Methods:
- A cross-sectional study was conducted.
- 313 patients with NB were included.
- Serum Cystatin-C levels were analyzed to estimate glomerular filtration rate (eGFR).
Main Results:
- CKD prevalence was 8.0% by sCr-based eGFR and 22.4% by Cystatin-C-based eGFR.
- Cystatin-C revealed a higher CKD prevalence than sCr, indicating sCr's inadequacy.
- Diabetes, small bladder volume, recurrent urinary tract infections, and proteinuria were significant risk factors for CKD.
Conclusions:
- CKD prevalence in NB patients is substantially higher than in the general population.
- Serum Cystatin-C is a more sensitive marker for CKD in NB patients.
- Managing comorbidities like diabetes and urinary tract infections is crucial for preventing CKD in NB.
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