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Folding and Characterization of a Bio-responsive Robot from DNA Origami
Published on: December 3, 2015
Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds
Yuanchen Dong1, Yuhe Renee Yang2, Yiyang Zhang1
1Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Abstract:
We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.
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