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Immuno-PET for Clinical Theranostic Approaches
Clément Bailly1,2, Pierre-François Cléry3, Alain Faivre-Chauvet4,5
1Nantes-Angers Cancer Research Center (CRCNA), University of Nantes, Inserm UMR 892, 8 quai Moncousu, 44007 Nantes, France. clement.bailly@chu-nantes.fr.
International Journal of Molecular Sciences
|December 31, 2016
Summary
Immuno-positron emission tomography (PET) uses antibody-based probes for personalized cancer medicine. This approach non-invasively assesses tumor targets, aiding diagnosis, treatment selection, and therapy monitoring.
Area of Science:
- Oncology
- Nuclear Medicine
- Molecular Imaging
Background:
- Advances in tumor molecular characterization identify novel biomarkers.
- Biomarker identification is crucial for personalized medicine and treatment decisions.
- Immuno-positron emission tomography (PET) aligns with personalized medicine strategies.
Purpose of the Study:
- To review recent developments in immuno-PET for theranostic applications.
- To highlight the role of monoclonal antibodies (mAbs) labeled with radionuclides as PET probes.
- To discuss applications of immuno-PET in clinical practice.
Main Methods:
- Review of labeling methods for radionuclides.
- Identification and discussion of relevant biological targets for immuno-PET.
- Analysis of recent clinical data for novel PET radiopharmaceuticals.
Main Results:
- Monoclonal antibodies labeled with radionuclides offer non-invasive in vivo assessment of target expression.
- Immuno-PET provides valuable data for patient stratification, diagnosis, and therapy selection.
- Emerging PET radiopharmaceuticals show promise for various clinical applications.
Conclusions:
- Immuno-PET is a powerful tool supporting personalized medicine in oncology.
- It enables non-invasive evaluation of molecular targets for theranostic purposes.
- Further development in labeling, targets, and clinical validation will enhance its utility.
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