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Updated: Mar 9, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Published on: September 12, 2019

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Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives

Catia Giovannini1,2, Luigi Bolondi3,4, Laura Gramantieri5

  • 1Centre for Applied Biomedical Research (CRBA), S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy. catia.giovannini4@unibo.it.

International Journal of Molecular Sciences
|December 31, 2016
PubMed

Insights

The Notch3 signaling pathway is crucial in liver cancer development and presents potential therapeutic targets. Its interaction with p53 is key for understanding hepatocellular carcinoma progression.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Signaling

Background:

  • The Notch signaling pathway regulates cell fate and stem cell maintenance via cell-to-cell communication.
  • Aberrant Notch signaling is implicated in various human diseases, notably cancer.
  • Notch pathway activation is common in many malignancies.

Purpose of the Study:

  • To review the role of Notch3 signaling in hepatocellular carcinoma (HCC).
  • To explore potential therapeutic strategies targeting Notch3 in HCC.
  • To highlight the significance of Notch-p53 crosstalk in HCC.

Main Methods:

  • Literature review of Notch signaling in cancer.
  • Focus on Notch3-specific mechanisms in HCC.
  • Analysis of studies investigating Notch pathway interactions.

Main Results:

  • Notch3 signaling plays a significant role in HCC pathogenesis.
  • Therapeutic targeting of Notch3 shows promise for HCC treatment.
  • The interplay between Notch and p53 is a critical factor in HCC.

Conclusions:

  • Notch3 is a relevant target for HCC therapy.
  • Understanding Notch-p53 interactions is vital for HCC treatment development.
Keywords:
Notchhepatocellular carcinoma (HCC)p53

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