Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fundamentals and Advances in Programmable Peptide Hydrogels for Multifunctional Biomedical Applications: A Review.

Gels (Basel, Switzerland)·2026
Same author

Therapeutic Effects of Nanoparticles Loaded with Combined Sense and Anti-Sense of EpoR Plasmids to Enhance Angiogenesis.

Research square·2026
Same author

Chikungunya fever in Guangdong, China, 2025: rapid spread and challenges.

Journal of thoracic disease·2026
Same author

Nasal Instillation of Complex Metal Oxide Particles Induces Brain Metal Accumulation and Neurobehavioral Toxicity in Mice.

Environmental science & technology·2026
Same author

Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics.

Signal transduction and targeted therapy·2026
Same author

Cardiac-Derived ECM Microspheres for Enhanced hiPSC-CMs Maturation.

Advanced functional materials·2026
Same journal

Synergistic Buried Interface Engineering via Ion Exchange and Passivation for High-Performance Inverted Perovskite Solar Cells.

ACS applied materials & interfaces·2026
Same journal

In Situ Wet Coating of Ammonium Phosphomolybdate for Enhancing the Kinetics and Cycling Stability of NaNi<sub>1/3</sub>Fe<sub>1/3</sub>Mn<sub>1/3</sub>O<sub>2</sub> Cathode Material.

ACS applied materials & interfaces·2026
Same journal

Molecular Hybrids of Serum Albumin and Cobalt Phthalocyanine for Asymmetric Oxidation of C=C and C-H Bonds.

ACS applied materials & interfaces·2026
Same journal

A High-Throughput Platform for Measuring and Predicting Vitrification Behavior in Multicomponent Aqueous Solutions.

ACS applied materials & interfaces·2026
Same journal

A Brain-Targeted DNA Delivery Nanocarrier Modulator for Synergistic Therapy of Parkinson's Disease.

ACS applied materials & interfaces·2026
Same journal

Quasi-Discrete Channels of Porous Coordination Polymers for Selective Multiscenario CO<sub>2</sub> Recognition.

ACS applied materials & interfaces·2026
See all related articles

Related Experiment Video

Updated: Mar 9, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

13.2K

Low-Initial-Modulus Biodegradable Polyurethane Elastomers for Soft Tissue Regeneration.

Cancan Xu1,2, Yihui Huang1,2, Liping Tang1,2

  • 1Department of Bioengineering, University of Texas at Arlington , Arlington, Texas 76019, United States.

ACS Applied Materials & Interfaces
|December 31, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed new biodegradable polyurethane scaffolds that mimic soft tissue mechanics. These elastomeric scaffolds show excellent biocompatibility and are promising for soft tissue regeneration, particularly for cardiac muscle repair.

Keywords:
biodegradableinitial modulusmechanical matchpolyurethaneporous scaffoldsoft tissue engineering

More Related Videos

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
06:59

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

8.4K
Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

10.2K

Related Experiment Videos

Last Updated: Mar 9, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

13.2K
Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
06:59

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

8.4K
Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

10.2K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Matching synthetic scaffold mechanics to host tissue is crucial for successful tissue regeneration.
  • Elastic soft tissues require scaffolds with low initial moduli and specific J-shaped tensile curves.
  • Existing synthetic polymers often struggle to meet these demanding mechanical and elastic requirements.

Purpose of the Study:

  • To synthesize and characterize biodegradable elastomeric polyurethanes (PU) with tunable low initial moduli for soft tissue regeneration.
  • To investigate the influence of soft segment composition (PVCL-PEG-PVCL) on the mechanical properties and biocompatibility of PU scaffolds.
  • To evaluate the potential of these novel PU scaffolds for applications in soft tissue repair, including cardiac muscle regeneration.

Main Methods:

  • Synthesized triblock copolymers (PVCL-PEG-PVCL) with varying molecular weights and hydrophilicities.
  • Developed biodegradable elastomeric polyurethanes (PU) using these copolymers as soft segments.
  • Characterized mechanical properties (dry and wet states), cell compatibility (fibroblast growth), and scaffold morphology (thermally induced phase separation).
  • Assessed in vivo tissue compatibility through subcutaneous implantation in mice.

Main Results:

  • Polyurethane mechanical properties, including initial moduli, were successfully tuned by altering soft segment molecular weights and hydrophilicities.
  • Increasing PVCL or PEG chain lengths in soft segments reduced the initial moduli of PU films and scaffolds.
  • Scaffolds exhibited good in vitro cell compatibility and supported fibroblast growth.
  • A PU scaffold (PU-PEG1K-PVCL6K) demonstrated an initial modulus comparable to human myocardium (0.60 ± 0.14 MPa).
  • In vivo studies showed minimal inflammation and significant cell infiltration, indicating excellent tissue compatibility.

Conclusions:

  • Biodegradable polyurethane elastomers with low initial moduli, good biocompatibility, and processability were developed.
  • These novel materials offer an attractive alternative for soft tissue regeneration scaffolds.
  • The tunable properties make them particularly suitable for applications like heart muscle regeneration.