Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

53.0K
Overview
53.0K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of WRSs2, a live-attenuated Shigella sonnei vaccine, against shigellosis in a controlled human infection model in the USA: a phase 2, double-blind, randomised, placebo-controlled trial.

The Lancet. Infectious diseases·2026
Same author

Alternative approaches to phase III clinical trials for vaccine efficacy and licensure: the role of real-world evidence - a meeting report.

Biologicals : journal of the International Association of Biological Standardization·2026
Same author

Human Nutrition and Oral Vaccine Efficacy.

Annual review of nutrition·2026
Same author

Prevalence of group B Streptococcus colonization in pregnant women and serotype specific immunity among mother-newborns dyads in Ghana and Zimbabwe.

Vaccine·2026
Same author

Waning of measles immunity by 5 years of age following an accelerated two-dose measles vaccine schedule at 6 and 12 months in South African children: an observational cohort study.

Vaccine·2026
Same author

Deaths with preceding hospitalisations within 180 days in eight countries in sub-Saharan Africa and South Asia: A secondary descriptive analysis of the Child Health and Mortality Prevention Surveillance (CHAMPS) network.

BMJ open·2026
Same journal

Epidemiological characteristics of amebiasis in Japan from 2001 to 2022.

PloS one·2026
Same journal

Longitudinal associations of academic stress with eating related patterns, nutrition, somatic indicators, and depressive symptoms in university students: A study protocol.

PloS one·2026
Same journal

Pollution removal efficiency enhancement by agricultural biomass additions in constructed wetlands: A framework integrating meta-analysis with explainable machine learning.

PloS one·2026
Same journal

Insulation failure mapping on power transformer bushing using FRA and electrostatic simulation.

PloS one·2026
Same journal

Enhancing medical Q&A systems with multimodal knowledge graphs and dual-layer attention mechanisms.

PloS one·2026
Same journal

UAMP: Consistent video object segmentation with uncertainty-aware memory propagation.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Mar 9, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

15.2K

Temporal Changes in Invasive Group B Streptococcus Serotypes: Implications for Vaccine Development.

Ziyaad Dangor1,2,3, Clare L Cutland1,2, Alane Izu1,2

  • 1Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Plos One
|December 31, 2016
PubMed
Summary
This summary is machine-generated.

Invasive group B Streptococcus (GBS) disease remains a significant threat in South Africa, with persistently high incidence rates. Serotype distribution shows shifts, with increasing Ia and decreasing III, impacting vaccine development strategies.

More Related Videos

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
06:06

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

2.2K
Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

3.9K

Related Experiment Videos

Last Updated: Mar 9, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

15.2K
Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
06:06

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

2.2K
Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

3.9K

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Vaccinology

Background:

  • Limited longitudinal data exists on the serotype-specific burden of invasive group B Streptococcus (GBS) disease in low-middle income countries.
  • Understanding GBS epidemiology is crucial for informing the selection of vaccine epitopes and developing effective prevention strategies.
  • South Africa, a setting with limited GBS data, provides a critical context for this research.

Purpose of the Study:

  • To determine the longitudinal, serotype-specific incidence of invasive GBS disease in infants in Soweto, South Africa.
  • To analyze trends in GBS serotype distribution over a decade.
  • To provide data that can inform the development of GBS vaccines.

Main Methods:

  • A decade-long surveillance study (2005-2014) was conducted at Chris Hani Baragwanath Academic Hospital, Soweto.
  • Invasive GBS disease cases were identified in infants younger than 90 days through sentinel laboratory and hospital admission surveillance.
  • Serotype-specific incidence and trends were calculated and analyzed.

Main Results:

  • A total of 820 invasive GBS cases were identified, with 55% being early-onset disease (EOD).
  • The overall incidence of invasive GBS disease was 2.59 per 1,000 live births.
  • Significant year-on-year changes included a 9.4% increase in serotype Ia and a 7.4% decrease in serotype III; serotypes Ia, III, and V were most common.

Conclusions:

  • Invasive GBS disease incidence remains persistently high in this South African setting.
  • While some shifts in serotype distribution were observed, the dominant serotypes largely remained consistent.
  • These findings highlight the ongoing burden of GBS and the need for effective interventions, including vaccination.