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Association between Gout and Erectile Dysfunction: A Systematic Review and Meta-Analysis.
Xing-Li Du1, Lei Liu2, Wen Song3
1Nursing Management Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Plos One
|December 31, 2016
Summary
This systematic review found a significant association between gout and erectile dysfunction (ED). Patients with gout have a higher likelihood of developing ED, underscoring the need for further research.
Area of Science:
- Urology
- Rheumatology
- Epidemiology
Background:
- Gout is a common inflammatory condition.
- Erectile dysfunction (ED) significantly impacts quality of life.
Purpose of the Study:
- To systematically review and meta-analyze the association between gout and erectile dysfunction (ED).
Main Methods:
- Comprehensive search of four major electronic databases (EMBASE, Pubmed, CENTRAL, ISI Web of Science) up to March 2016.
- Independent, blinded screening of articles by reviewers.
- Meta-analysis conducted using RevMan 5.3.
Main Results:
- Five studies with 56,465 gout patients and 155,636 controls were analyzed.
- Gout patients showed a 1.44 times higher likelihood of ED (unadjusted OR).
- Adjusted analysis confirmed a persistent heightened risk (OR 1.18), with significant associations across all age groups.
Conclusions:
- A positive association exists between gout and erectile dysfunction (ED).
- Study heterogeneity limits definitive causal conclusions.
- Further large-scale, homogeneous population studies and RCTs are recommended to explore gout treatment effects on ED.
