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Execution time determines the outcome of the multicenter randomized controlled trials.
Yongjun Jiang1, Qijin Zhai2, Zheng Dai1
1Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Nanjing 210002, China.
International Journal of Cardiology
|January 1, 2017
Summary
Execution time is the key factor for successful multicenter randomized controlled trials. Shorter trial durations correlate with significant outcomes in cardiovascular disease research, not the number of centers or participants.
Area of Science:
- Cardiology
- Clinical Trials
- Evidence-Based Medicine
Background:
- Multicenter randomized controlled trials are foundational to evidence-based medicine.
- Investigating factors influencing trial outcomes is crucial for optimizing research.
- Cardiovascular diseases remain a leading global health concern.
Purpose of the Study:
- To identify the critical determinant of success in multicenter randomized controlled trials.
- To analyze the impact of various trial parameters on study outcomes.
Main Methods:
- Systematic literature search of PubMed for multicenter randomized controlled trials.
- Data extraction on cardiovascular disease treatment and prevention trials.
- Statistical analysis to assess the influence of trial characteristics on outcomes.
Main Results:
- 1075 trials were analyzed, focusing on heart disease (979) and stroke (96).
- Shorter execution times were significantly associated with positive trial outcomes.
- The number of participating centers, their locations, and participant numbers did not significantly affect trial outcomes.
Conclusions:
- Trial execution time is a significant predictor of outcome in multicenter randomized controlled trials.
- Factors such as the number of centers and participants do not appear to influence trial success.
- Optimizing trial duration is essential for achieving significant results in cardiovascular research.
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