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Inflammaging and human longevity in the omics era.

Daniela Monti1, Rita Ostan2, Vincenzo Borelli2

  • 1Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

Mechanisms of Ageing and Development
|January 1, 2017
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Summary
This summary is machine-generated.

Inflammaging, the aging of the immune system, is a complex, dynamic, and systemic process. New omics data reveals its intricate structure and propagation, necessitating a Systems Medicine approach for better understanding.

Keywords:
AgingCentenariansInflammagingN-glycansSystems medicine

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Area of Science:

  • Gerontology
  • Immunology
  • Systems Biology

Background:

  • Inflammaging theory, proposed in 2000, integrates immunosenescence and evolutionary immunology.
  • It has gained significant traction with increasing citations and experimental validation.
  • This study updates the inflammaging concept using omics data from centenarians and their offspring.

Purpose of the Study:

  • To present an updated version of the inflammaging theory.
  • To analyze omics data, with a focus on glycomics, from centenarians, semi-supercentenarians, and their offspring.
  • To elucidate the complex molecular mechanisms underlying inflammaging.

Main Methods:

  • Analysis of omics data, particularly glycomics.
  • Study population included centenarians, semi-supercentenarians, and their offspring.
  • Integration of data to understand systemic and dynamic aspects of inflammaging.

Main Results:

  • Inflammaging exhibits a defined structure involving pro- and anti-inflammatory mediators.
  • It is a systemic process involving multiple organs, tissues, and cell types producing "molecular garbage".
  • Inflammaging is dynamic, propagating locally and systemically, and amplified by chronic diseases.

Conclusions:

  • A specific combinatorial structure of inflammatory mediators characterizes inflammaging.
  • Inflammaging is a complex, systemic, and dynamic phenomenon involving "molecular garbage" production.
  • An integrated Systems Medicine approach using omics markers is crucial for understanding inflammaging in the elderly.