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Age-specific Incidence and Prevalence of Keratoconus: A Nationwide Registration Study
Daniel A Godefrooij1, G Ardine de Wit2, Cuno S Uiterwaal3
1Utrecht Cornea Research Group, Department of Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands.
Purpose:
To determine the age-specific incidence and prevalence of keratoconus in the modern era of diagnostics.
Design:
Epidemiologic study.
Participants:
Total of 4.4 million patients from a mandatory health insurance database.
Methods:
Data were extracted from the largest health insurance provider in the Netherlands. Patients aged 10-40 years were defined as the relevant age category for newly diagnosed keratoconus and the annual incidence of newly diagnosed keratoconus was determined. The prevalence of keratoconus was estimated based on the annual incidence, mean age at diagnosis, and average life expectancy. Main outcome measure was the annual incidence and prevalence of keratoconus.
Results:
The annual incidence of keratoconus was 1:7500 in the relevant age category (13.3 cases per 100 000, 95% confidence interval [CI]: 11.6-15.2) and the estimated prevalence of keratoconus in the general population was 1:375 (265 cases per 100 000, 95% CI: 260-270). These values are 5-fold to 10-fold higher than previously reported values in population studies. The mean age at diagnosis was 28.3 years and 60.6% of diagnosed patients were male.
Conclusions:
Both the annual incidence and the prevalence of keratoconus were 5-fold to 10-fold higher than previously reported.
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