Impulsive oculomotor action selection in Parkinson's disease
Joan Duprez1, Jean-François Houvenaghel2, Soizic Argaud3
1"Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Avenue du Professeur Léon Bernard, 35000 Rennes, France.
Neuropsychologia
|January 1, 2017
Summary
Parkinson's disease (PD) impairs action selection, leading to more impulsive choices and faster errors. However, impulse suppression remains intact, and both aspects of impulsivity link to self-reported traits.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Behavioral Science
Background:
- Parkinson's disease (PD) effects on action control are debated, with mixed results on impulsive action selection.
- Impulsivity as a trait may share mechanisms with behavioral measures of action control.
Purpose of the Study:
- To clarify PD's impact on impulsive action selection and suppression.
- To investigate the relationship between cognitive action control and self-reported impulsivity in PD.
Main Methods:
- Administered an oculomotor Simon task to 32 PD patients and 32 healthy controls (HC).
- Utilized distributional analyses based on the activation-suppression model.
- Assessed trait impulsivity using the Barratt Impulsiveness Scale (BIS).
Main Results:
- PD patients showed faster overall responses and a greater congruence effect than HC.
- Patients exhibited enhanced impulsive action selection and a higher rate of fast errors.
- Impulse suppression was comparable between groups; higher BIS scores correlated with increased impulsive action selection and suppression in PD patients.
Conclusions:
- PD increases susceptibility to impulsive action selection, particularly with irrelevant stimulus dimensions.
- Both action selection and suppression aspects of impulsivity are linked to trait impulsivity, suggesting shared underlying mechanisms.
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