Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

3.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.8K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

5.0K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
5.0K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.2K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K
Liver Histology01:27

Liver Histology

5.3K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
5.3K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing the performance and interpretability of epigenetic clocks.

Nucleic acids research·2026
Same author

The landscape of dementia in India: Prevalence, risk factors, and opportunities ahead.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Efficacy and Safety of High-Dose Multimatrix Mesalazine in Pediatric Patients with Mild-to-Moderate Active Ulcerative Colitis.

Pediatric gastroenterology, hepatology & nutrition·2026
Same author

CAR-T cells directed toward PD-L1 demonstrate potent, antigen-specific activity against cholangiocarcinoma: A proof of concept study.

Molecular therapy. Oncology·2026
Same author

Cell-SELEX identifies a DNA aptamer for highly selective in vivo siRNA delivery in cholangiocarcinoma.

JHEP reports : innovation in hepatology·2026
Same author

Real-World Analysis of Multidisciplinary Roles in the Management of Hepatocellular Carcinoma: The Mayo Clinic Experience.

Journal of hepatocellular carcinoma·2026

Related Experiment Video

Updated: Mar 9, 2026

Isolation of Tissue Extracellular Vesicles from the Liver
05:39

Isolation of Tissue Extracellular Vesicles from the Liver

Published on: August 21, 2019

12.5K

Extracellular vesicles in liver diseases.

Sayantan Maji1, Akiko Matsuda1, Irene K Yan1

  • 1Department of Transplantation and Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida.

American Journal of Physiology. Gastrointestinal and Liver Physiology
|January 1, 2017
PubMed
Summary

Extracellular vesicles (EVs) mediate cell communication and play a role in liver diseases like hepatitis and cancer. Studying EVs offers new opportunities for disease markers and therapeutics.

Keywords:
cancerextracellular vesiclesliver diseasesmicroRNA

More Related Videos

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
10:33

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

Published on: February 3, 2023

1.7K
Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues
09:57

Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues

Published on: October 17, 2022

2.9K

Related Experiment Videos

Last Updated: Mar 9, 2026

Isolation of Tissue Extracellular Vesicles from the Liver
05:39

Isolation of Tissue Extracellular Vesicles from the Liver

Published on: August 21, 2019

12.5K
An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
10:33

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

Published on: February 3, 2023

1.7K
Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues
09:57

Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues

Published on: October 17, 2022

2.9K

Area of Science:

  • Cell Biology
  • Hepatology
  • Biochemistry

Background:

  • Extracellular vesicles (EVs) are released by cells and mediate intercellular communication.
  • EVs contain specific proteins and RNA, reflecting their cell of origin.
  • Their role in liver pathophysiology is an emerging area of research.

Purpose of the Study:

  • To review the recent findings on the role of EVs in various liver conditions.
  • To explore the potential of EVs as biomarkers for liver diseases.
  • To discuss the therapeutic applications of EVs in liver disease management.

Main Methods:

  • Literature review of recent studies on extracellular vesicles and liver disease.
  • Analysis of the role of EVs in liver injury, viral hepatitis, alcoholic/nonalcoholic liver disease, biliary tract disease, and liver cancers.
  • Evaluation of current and future applications of EVs in diagnostics and therapeutics.

Main Results:

  • EVs are implicated in the pathogenesis and progression of diverse liver diseases.
  • Specific EV components show promise as diagnostic or prognostic biomarkers.
  • EVs hold potential for targeted drug delivery and regenerative medicine in liver disorders.

Conclusions:

  • Extracellular vesicles are crucial mediators in liver disease.
  • Further research into EVs can lead to novel diagnostic and therapeutic strategies for liver conditions.
  • The study of EVs opens new avenues for understanding and treating liver pathologies.