Related Experiment Video

Updated: Mar 9, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K

Long-term prognosis associated with early repolarisation pattern in Chinese population with atherosclerotic risk

Yun-Jiu Cheng1, Wei-Yi Mei1, Xu-Miao Chen1

  • 1Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Heart (British Cardiac Society)
|January 1, 2017
PubMed

Insights

Early repolarization pattern (ERP) significantly increases the risk of sudden cardiac death (SCD) and overall mortality in individuals with atherosclerotic risk factors. This finding highlights ERP as a crucial prognostic marker for cardiovascular events in high-risk populations.

Area of Science:

  • Cardiology
  • Electrocardiography
  • Preventive Cardiology

Background:

  • Early repolarization pattern (ERP) is linked to sudden cardiac death (SCD) in individuals without structural heart disease.
  • The prognostic value of ERP in patients with atherosclerotic heart disease remains unclear.

Purpose of the Study:

  • To investigate the prognostic significance of ERP in a large population at high risk for atherosclerotic heart disease.
  • To determine the association between ERP and risks of sudden cardiac death, coronary heart disease death, and all-cause mortality.

Main Methods:

  • Prospective assessment of 18,231 subjects with atherosclerotic risk factors.
  • ECG analysis for ERP and follow-up for 7.6 years.
  • Cox proportional hazards models used for risk estimation, adjusted for confounders.

Main Results:

  • ERP was associated with a significantly increased risk of SCD (HR 1.91), coronary heart disease (CHD) death (HR 1.80), and all-cause mortality (HR 1.35).
  • Specific ERP features (inferior leads, J wave amplitude, notching, ST segment) indicated higher SCD risk.
  • An absolute increase of 52.3 SCDs per 100,000 person-years was observed in this high-risk population.

Conclusions:

  • ERP is a significant predictor of SCD, CHD death, and all-cause mortality in individuals with atherosclerotic risk factors.
  • The association of ERP with all-cause mortality is primarily driven by SCD risk.
  • ERP is a valuable prognostic marker for cardiovascular events in populations at high risk for atherosclerotic disease.
Abstract

More Related Videos

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

706
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
602
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
357
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
541
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
857
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.4K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.7K