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Updated: Mar 9, 2026
Biomechanical Testing of Murine Tendons
Published on: October 15, 2019
Burst inflation test for measuring biomechanical properties of rat abdominal walls
V D Mahalingam1,2, B C Syverud3, A M Myers4
1Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA. vasum@umich.edu.
Purpose:
Evaluation of potential grafts to improve upon current strategies for abdominal wall (AW) repair in small animal models typically involves mechanical testing using methods that currently are inadequate to assess physiologically relevant parameters. This study introduces burst inflation testing as a more relevant assessment of the mechanical integrity of the AW compared to traditional tensile testing.
Methods:
AWs were excised from 14 healthy adult Fischer 344 rats and tested using either a custom burst inflation device or an Instron tensile testing system. Modulus outcomes from both testing methods were compared.
Results:
Mechanical analyses of native AW using burst and tensile testing methods resulted in similar average tissue moduli, but with the burst test, there was significantly less variability among specimens.
Conclusions:
The burst test had greater repeatability compared to tensile testing and has the ability to test repaired AWs without compromising the integrity of the repair site, making it a useful tool for assessing graft repairs.
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