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Implications of oxidative stress on viral pathogenesis
Fernanda Caetano Camini1, Camila Carla da Silva Caetano1, Letícia Trindade Almeida1
1Núcleo de Pesquisas em Ciências Biológicas, NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Archives of Virology
|January 1, 2017
Summary
Viral infections can cause oxidative stress due to an imbalance in reactive species. Targeting this oxidative stress may offer new therapeutic strategies for viral diseases.
Area of Science:
- Biochemistry
- Virology
- Pathogenesis
Background:
- Viral infections trigger the formation of reactive species.
- Antioxidant defenses may be insufficient to counteract reactive species, leading to oxidative stress.
- Oxidative stress is an imbalance between reactive species production and detoxification.
Purpose of the Study:
- To analyze the role of oxidative stress in viral infection pathogenesis.
- To highlight therapeutic strategies for controlling virus-induced oxidative injury.
- To review the impact of oxidative stress on DNA, RNA, and retroviral infections.
Main Methods:
- Literature review of viral pathogenesis and oxidative stress.
- Analysis of antioxidant defense mechanisms.
- Focus on specific viral families: papillomaviruses, hepadnaviruses, flaviviruses, orthomyxoviruses, paramyxoviruses, togaviruses, and human immunodeficiency virus.
Main Results:
- Viruses disrupt the cellular redox environment, causing an imbalance in reactive species.
- This imbalance can trigger various cellular responses, including altered cell signaling and antioxidant defenses.
- Oxidative stress plays a significant role in the pathogenesis of diverse viral infections.
Conclusions:
- Modulating reactive species production and oxidative stress is a potential pharmacological approach.
- Targeting oxidative stress may reduce the consequences of viral pathogenesis.
- Understanding virus-induced oxidative injury is crucial for developing novel antiviral therapies.
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