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UVB-generated Microvesicle Particles: A Novel Pathway by Which a Skin-specific Stimulus Could Exert Systemic Effects
Katherine Fahy1, Langni Liu1, Christine M Rapp1
1Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH.
Photochemistry and Photobiology
|January 1, 2017
Summary
Ultraviolet B (UVB) radiation stimulates skin cells to produce microvesicle particles (MVPs). These UVB-MVPs may transmit bioactive agents from the epidermis, offering a new target for modulating UVB effects.
Area of Science:
- Dermatology
- Cell Biology
- Biochemistry
Background:
- Ultraviolet B (UVB) radiation significantly impacts human skin.
- UVB generates numerous bioactive agents like cytokines, proteins, lipid mediators, and microRNAs within the epidermis.
- The precise mechanisms by which these agents exit the epidermis remain unclear.
Purpose of the Study:
- To explore the role of microvesicle particles (MVPs) as signaling agents in UVB-induced skin responses.
- To investigate the potential of MVPs in transmitting bioactive mediators from keratinocytes.
Main Methods:
- Review of existing literature on UVB effects and intercellular communication.
- Presentation of new data from UVB-treated human skin explants.
- Hypothesis formulation based on experimental observations.
Main Results:
- UVB treatment of human skin explants demonstrably generates MVP production.
- UVB-induced MVPs (UVB-MVPs) are proposed as a mechanism for transmitting keratinocyte-derived bioactive agents.
- Platelet-activating factor is hypothesized to be involved in UVB-MVP formation.
Conclusions:
- UVB-MVPs represent a novel pathway for intercellular signaling in the skin.
- This pathway facilitates the transmission of UVB-induced bioactive mediators.
- Targeting UVB-MVP formation offers a potential pharmacological strategy to modulate UVB-induced skin effects.
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