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How Well Do Children with Cystic Fibrosis Sleep? An Actigraphic and Questionnaire-Based Study

Moya Vandeleur1, Lisa M Walter2, David S Armstrong3

  • 1The Ritchie Centre, Department of Pediatrics, Monash University and Hudson Institute of Medical Research, Melbourne, Victoria, Australia; Department of Respiratory Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.

The Journal of Pediatrics
|January 2, 2017
PubMed

Insights

Children with cystic fibrosis (CF) experience poorer sleep quality and efficiency than healthy peers, even when clinically stable. Sleep disturbances in CF are linked to disease severity, impacting daytime alertness.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Clinical Research

Background:

  • Cystic Fibrosis (CF) affects multiple organ systems, including potentially impacting sleep.
  • Objective and subjective sleep assessment is crucial for understanding the overall health of children with CF.

Purpose of the Study:

  • To objectively and subjectively measure sleep patterns and quality in clinically stable children with CF compared to healthy controls.
  • To investigate the relationship between sleep quality and CF disease severity.

Main Methods:

  • Actigraphy for 14 days to assess sleep patterns and quality.
  • Pulse oximetry for overnight peripheral capillary oxygen saturation.
  • Pediatric Daytime Sleepiness Scale (PDSS), Sleep Disturbance Scale for Children, and Obstructive Sleep Apnea-18 for subjective assessments.

Main Results:

  • Children with CF exhibited significantly lower total sleep time and sleep efficiency than controls, with more frequent awakenings.
  • CF disease severity markers (e.g., FEV1, oxygen saturation) correlated with sleep parameters.
  • Children with CF reported significantly higher sleep disturbance and daytime sleepiness scores.

Conclusions:

  • Children with CF have impaired sleep quality and efficiency, even during clinical stability, characterized by increased nighttime wakefulness.
  • Objective sleep disturbances and subjective daytime sleepiness in CF are associated with disease severity.
  • Parental reports of sleep disturbance may not always align with objective measures or disease severity.
Abstract

Keywords:
actigraphydaytime sleepinesssleep diaries

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