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The role of electronegative low-density lipoprotein in cardiovascular diseases and its therapeutic implications

Sumeyya Akyol1, Jonathan Lu2, Omer Akyol3

  • 1Vascular & Medicinal Research, Texas Heart Institute, 6770 Bertner Avenue, MC 2-255, Houston, TX 77030, USA; Department of Medical Biology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.

Trends in Cardiovascular Medicine
|January 2, 2017
PubMed

Insights

Low-density lipoprotein (LDL) subfraction L5, the most electronegative, uniquely induces an atherogenic response. This review explores L5

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Atherosclerosis Research

Background:

  • Cardiovascular disease (CVD) poses significant public health challenges.
  • Low-density lipoprotein (LDL) is implicated in CVD development and progression.
  • Emerging research identifies distinct LDL subfractions with varying effects on endothelial function.

Purpose of the Study:

  • To review current knowledge on the association between LDL subfraction L5 and CVD.
  • To elucidate the specific role of L5 in the pathophysiology of CVD.
  • To highlight L5's contribution to atherosclerosis.

Main Methods:

  • Literature review of studies investigating LDL subfractions and endothelial function.
  • Analysis of research on the atherogenic properties of LDL subfraction L5.
  • Synthesis of data on L5's impact on cardiovascular pathophysiology.

Main Results:

  • LDL subfraction L5 is the most electronegative LDL particle.
  • L5 demonstrates a unique ability to induce an atherogenic response.
  • Evidence suggests L5 plays a critical role in atherosclerosis development.

Conclusions:

  • LDL subfraction L5 is a key factor in CVD pathogenesis.
  • Understanding L5's mechanisms is crucial for CVD prevention and treatment.
  • Targeting L5 may offer novel therapeutic strategies for atherosclerosis.

Keywords:
Cardiovascular diseaseElectronegative low-density lipoproteinL5

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