Related Experiment Video
Updated: Mar 9, 2026
05:30
Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules
Published on: August 16, 2011
18.8K
(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
Céline Cosseau1, Olaf Wolkenhauer2, Gilda Padalino3
1University Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, University Montpellier, F-66860 Perpignan, France.
Trends in Parasitology
|January 2, 2017
Summary
We expanded the genotype-environment interaction concept to include the genome and epigenome, collectively termed the inheritance system. This system influences infection success in Schistosoma mansoni, impacting global health.
Area of Science:
- Genetics and Epigenetics
- Systems Biology
- Parasitology
Background:
- The genotype × environment (G×E) interaction model explains biological phenomena.
- Phenotype development is influenced by the interplay between genetic and environmental factors.
Purpose of the Study:
- To propose an extended concept of G×E interactions, incorporating both genomic and epigenomic elements.
- To investigate the role of these interactions in shaping phenotypic traits relevant to global health.
Main Methods:
- Systems biology approach
- Analysis of genetic and epigenetic interactions
- Focus on Schistosoma mansoni infection success
Main Results:
- The inheritance system (genome + epigenome) interacts with the environment to shape phenotypes.
- Genetic and epigenetic interactions drive both temporary and heritable phenotypic variations.
- These variations are critical for infection success in Schistosoma mansoni.
Conclusions:
- The extended inheritance system concept provides a more comprehensive framework for understanding phenotype development.
- Epigenetic modifications play a significant role in adaptive phenotypic variation.
- Understanding these interactions is crucial for addressing parasitic diseases like schistosomiasis.
Related Concept Videos
01:09Epistasis Analysis
6.0K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
6.0K
01:39Epistasis
50.8K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
50.8K
00:58Symbiosis
38.0K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
38.0K
02:30Genomic Imprinting and Inheritance
38.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
38.2K
01:43Incomplete Dominance
31.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
31.6K
01:39Chromosomal Theory of Inheritance
61.0K
In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.”
61.0K