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Published on: September 27, 2013
Novel four-sided neural probe fabricated by a thermal lamination process of polymer films
Soowon Shin1, Jae-Hyun Kim2, Joonsoo Jeong1
1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea; Inter-University Semiconductor Research Center, Seoul National University, Seoul, Republic of Korea.
Background:
Ideally, neural probes should have channels with a three-dimensional (3-D) configuration to record the activities of 3-D neural circuits. Many types of 3-D neural probes have been developed; however, most of them were designed as an array of multiple shanks with electrodes located along one side of the shanks.
New Method:
We developed a novel liquid crystal polymer (LCP)-based neural probe with four-sided electrodes. This probe has electrodes on four sides of the shank, i.e., the front, back and two sidewalls. To generate the proposed configuration of the electrodes, we used a thermal lamination process involving LCP films and laser micromachining.
Results:
The proposed novel four-sided neural probe, was used to successfully perform in vivo multichannel neural recording in the mouse primary somatosensory cortex.
Comparison With Existing Method:
The multichannel neural recording showed that the proposed four-sided neural probe can record spiking activities from a more diverse neuronal population than single-sided probes. This was confirmed by a pairwise Pearson correlation coefficient (Pearson's r) analysis and a cross-correlation analysis.
Conclusion:
The developed four-sided neural probe can be used to record various signals from a complex neural network.
