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Updated: Mar 9, 2026

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Wilms Tumor With Metastasis to the Vagina: A Case Report
Adam S Howe1, Bradley A Morganstern2, Heather Appelbaum3
1Division of Pediatric Urology, Cohen Children's Medical Center, Hofstra Northwell School of Medicine, Long Island, NY; Division of Pediatric Gynecology, Cohen Children's Medical Center, Hofstra Northwell School of Medicine, Long Island, NY.
Abstract:
A 12-year-old female presented with abdominal pain, night sweats, weight loss, constipation, dysmenorrhea, menorrhagia, and vaginal discharge. Examination revealed a palpable flank mass and a large tumor adherent to the anterior vaginal wall. Computed tomography scan demonstrated a 23 cm mass in the left kidney, a separate 10.8 cm pelvic mass, and metastatic disease. Biopsies were consistent with Wilms tumor. Neoadjuvant chemotherapy and a left radical nephrectomy were performed for her stage IV disease as the kidney was amiable to complete resection. The patient received radiation and resumed chemotherapy. She was doing well with improved symptoms at follow-up.
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