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Published on: January 26, 2024
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Proteinuria during dengue fever in children
Anne-Claire Andries1, Veasna Duong1, Julien Cappelle2
1Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia.
Summary
Proteinuria in children with dengue fever is common, but urine dipstick and UPCR are not ideal for initial patient triage. A decreasing UPCR may signal recovery from dengue.
Area of Science:
- Pediatric Infectious Diseases
- Nephrology
- Clinical Diagnostics
Background:
- Dengue fever is a significant global health concern, particularly in pediatric populations.
- Proteinuria, the presence of abnormal amounts of protein in the urine, can occur during dengue infection.
- Understanding proteinuria's role may aid in managing dengue patients.
Purpose of the Study:
- To investigate the occurrence of proteinuria in children diagnosed with dengue.
- To evaluate the utility of proteinuria measurements in clinical dengue management.
Main Methods:
- Assessed proteinuria using urine dipstick tests.
- Quantified proteinuria via urine protein:creatinine ratio (UPCR).
- Compared samples from hospitalized dengue patients with healthy controls.
Main Results:
- Dipstick proteinuria was more frequent in dengue patients (42.9%) than controls (20.0%).
- UPCR levels peaked during the critical phase of dengue, then declined with recovery.
- Proteinuria by UPCR was associated with warning signs or severe dengue at admission, though sensitivity was limited.
Conclusions:
- Urine dipstick and UPCR lack significant value for initial dengue patient triage.
- A decreasing UPCR trend during illness suggests patient recovery.
- Further research may refine the role of proteinuria in dengue management.
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