Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.1K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.8K
3.8K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.3K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.3K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.2K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.2K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

1.1K
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.1K
RNA Splicing01:32

RNA Splicing

61.1K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
61.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assembly and phylogenetic analysis of the mitochondrial genome of endangered medicinal plant Huperzia crispata.

Functional & integrative genomics·2023
Same author

Genomic diversity and evolution analysis of severe fever with thrombocytopenia syndrome in East Asia from 2010 to 2022.

Frontiers in microbiology·2023
Same author

Advances and challenges in biotechnological production of chondroitin sulfate and its oligosaccharides.

International journal of biological macromolecules·2023
Same author

lncRNA ARAP1-AS1 enhances proliferation and impairs apoptosis of lymphoma cells by sponging miR-6867-5p.

Cancer biomarkers : section A of Disease markers·2023
Same author

Pharmacological effects and mechanism of Kaihoujian Throat Spray (children's type) in the treatment of pediatric acute pharyngitis and tonsillitis.

Heliyon·2023
Same author

Computational Quantification of Cancer Immunoediting.

Cancer immunology research·2023
Same journal

Retraction: Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression.

Oncotarget·2026
Same journal

TRAIL-R2 in the shadows: Epigenetic silencing and clinical implications in breast cancer.

Oncotarget·2026
Same journal

Retraction: MALAT1 predicts poor survival in osteosarcoma patients and promotes cell metastasis through associating with EZH2.

Oncotarget·2026
Same journal

Laryngeal leiomyosarcoma: A rare case report and literature review.

Oncotarget·2026
Same journal

Correction: Postsurgery fluids promote transition of cancer stem cell toendothelial and AKT/mTOR activity contributing to relapse of giant cell tumors of bone.

Oncotarget·2026
Same journal

DHHC3 interferes with antitumor immunity in melanoma cells.

Oncotarget·2026
See all related articles

Related Experiment Video

Updated: Mar 9, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K

Dysregulated long intergenic non-coding RNA modules contribute to heart failure.

Lin Pang1, Jing Hu1, Guanxiong Zhang1

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.

Oncotarget
|January 2, 2017
PubMed
Summary
This summary is machine-generated.

Long intergenic non-coding RNAs (lincRNAs) are key regulators in heart failure. This study identifies a heart-specific lincRNA module linked to disease severity and left ventricular function, suggesting new biomarkers and therapeutic targets.

Keywords:
ceRNAcontractionheart failureheart specificitylincRNAmodule

More Related Videos

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.4K

Related Experiment Videos

Last Updated: Mar 9, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.4K

Area of Science:

  • Molecular Biology
  • Genomics
  • Cardiovascular Research

Background:

  • Long intergenic non-coding RNAs (lincRNAs) are increasingly recognized for their roles in disease pathogenesis.
  • The collaborative mechanisms between lincRNAs and protein-coding genes (PCGs) in heart failure remain largely unexplored.

Purpose of the Study:

  • To comprehensively profile the transcriptomes of lincRNAs, PCGs, and miRNAs in heart failure (HF) patients.
  • To identify and characterize HF-associated lincRNA modules and their functional roles.
  • To explore the potential of lincRNAs as biomarkers and therapeutic targets in heart failure.

Main Methods:

  • RNA sequencing (RNA-seq) and miRNA sequencing (miRNA-seq) were performed on samples from 16 heart failure patients and 8 non-failing individuals.
  • Integration of lincRNA and PCG expression profiles to identify disease-associated modules.
  • Correlation analysis between lincRNA modules and clinical traits, including left ventricular function indicators.

Main Results:

  • A heart-specific lincRNA module significantly enriched for differentially expressed lincRNAs and PCGs was identified.
  • This module was specifically associated with heart failure, independent of clinical factors like age, sex, smoking, and diabetes.
  • The lincRNA module demonstrated significant correlations with left ventricular function parameters (e.g., ejection fraction) and may function as competing endogenous RNAs (ceRNAs).

Conclusions:

  • lincRNAs play critical roles in the pathology of heart failure.
  • A specific lincRNA module is strongly associated with heart failure and cardiac function.
  • These findings highlight lincRNAs as potential valuable biomarkers and therapeutic targets for heart failure.