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[Delayed posthypoxic leucoencephalopathy after suicide attempt with opioids].

Moshgan Amiri1, Line Sofie Lunde Larsen

  • 1moshgan.amiri@regionh.dk.

Ugeskrift for Laeger
|January 3, 2017
PubMed
Summary

Delayed posthypoxic leucoencephalopathy (DPHL) is a rare neurological condition. It presents with subacute neurological and neuropsychological symptoms weeks after a hypoxic event, often following opioid overdose.

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Area of Science:

  • Neurology
  • Neuroimaging

Background:

  • Delayed posthypoxic leucoencephalopathy (DPHL) is a rare neurological disorder.
  • It is characterized by neurological and neuropsychological deficits appearing after an initial recovery period from acute hypoxia.

Observation:

  • The study presents a case of DPHL in a patient with a history of opioid-induced suicide attempt.
  • The patient exhibited symptoms and MRI findings consistent with DPHL.

Findings:

  • MRI revealed symmetric subcortical white matter lesions, a hallmark of DPHL.
  • The patient's presentation occurred four weeks after the hypoxic event.

Implications:

  • DPHL should be considered in the differential diagnosis for patients presenting with subacute neurological and neuropsychological symptoms post-hypoxia.

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  • Early recognition and consideration of DPHL are crucial for appropriate patient management.