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[Delayed posthypoxic leucoencephalopathy after suicide attempt with opioids]
Moshgan Amiri1, Line Sofie Lunde Larsen
1moshgan.amiri@regionh.dk.
Abstract:
Delayed posthypoxic leucoencephalopathy (DPHL) is a rare condition with manifestation of neurological and neuropsychological symptoms, following an acute hypoxic condition with an intermittent recovery period of four weeks. MRI findings show symmetric subcortical white matter lesions. We present a patient admitted with symptoms and brain MRI-scan consistent with DPHL. Four weeks prior the patient had tried to commit suicide with opioids. DPHL should be considered in patients with subacute onset of neurological and neuropsychological symptoms after an acute hypoxic condition of the brain.
Insights
Delayed posthypoxic leucoencephalopathy (DPHL) is a rare neurological condition. It presents with subacute neurological and neuropsychological symptoms weeks after a hypoxic event, often following opioid overdose.
Area of Science:
- Neurology
- Neuroimaging
Background:
- Delayed posthypoxic leucoencephalopathy (DPHL) is a rare neurological disorder.
- It is characterized by neurological and neuropsychological deficits appearing after an initial recovery period from acute hypoxia.
Observation:
- The study presents a case of DPHL in a patient with a history of opioid-induced suicide attempt.
- The patient exhibited symptoms and MRI findings consistent with DPHL.
Findings:
- MRI revealed symmetric subcortical white matter lesions, a hallmark of DPHL.
- The patient's presentation occurred four weeks after the hypoxic event.
Implications:
- DPHL should be considered in the differential diagnosis for patients presenting with subacute neurological and neuropsychological symptoms post-hypoxia.
- Early recognition and consideration of DPHL are crucial for appropriate patient management.
