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Inflammation and sarcopenia: A systematic review and meta-analysis
Giulia Bano1, Caterina Trevisan1, Sara Carraro1
1Department of Medicine, Geriatrics Section, University of Padova, Italy.
Maturitas
|January 3, 2017
Summary
Sarcopenia, a condition of muscle wasting, is linked to higher C-reactive protein (CRP) levels. However, Interleukin-6 and TNF-alpha levels did not show a significant association in this meta-analysis of inflammatory markers.
Area of Science:
- Gerontology
- Immunology
- Physiology
Background:
- Inflammatory cytokines are implicated in muscle wasting by promoting protein breakdown and inhibiting synthesis.
- The precise relationship between inflammatory markers and sarcopenia remains unclear.
- Understanding this link is crucial for developing targeted interventions.
Purpose of the Study:
- To conduct a meta-analysis summarizing evidence on serum inflammatory parameters in sarcopenia.
- To compare inflammatory cytokine levels between individuals with and without sarcopenia.
Main Methods:
- Systematic search of PubMed and Scopus databases up to September 2016.
- Meta-analysis of 17 cross-sectional studies involving 11,249 participants.
- Calculation of standardized mean differences (SMDs) for serum inflammatory markers.
Main Results:
- Sarcopenic individuals exhibited significantly higher C-reactive protein (CRP) levels (SMD=0.51).
- No significant differences in serum Interleukin-6 (IL-6) levels were found between groups (SMD=0.35).
- Tumor Necrosis Factor-alpha (TNF-α) levels were also not significantly elevated in sarcopenic participants (SMD=0.28).
Conclusions:
- Sarcopenia appears to be associated with elevated serum CRP levels.
- Further longitudinal research is necessary to elucidate the causal relationship between inflammation and sarcopenia.
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