Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

321
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
321
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

336
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
336
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

259
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
259

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subnanosecond phase transition dynamics in laser-shocked iron.

Science advances·2020
Same author

The cost of implanting a cemented <i>versus</i> cementless total knee arthroplasty.

The bone & joint journal·2019
Same author

Does patient-reported perception of pain differ based on surgical approach in total hip arthroplasty?

The bone & joint journal·2019
Same author

Changes in acetabular orientation during total hip arthroplasty.

The bone & joint journal·2019
Same author

Is a modular dual mobility acetabulum a viable option for the young, active total hip arthroplasty patient?

The bone & joint journal·2019
Same author

First Published Report of Rust on White Alder Caused by Melampsoridium hiratsukanum in the United States.

Plant disease·2019

Related Experiment Video

Updated: Mar 9, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

3.7K

Obesity in total hip arthroplasty: does it make a difference?

J Haynes1, D Nam1, R L Barrack1

  • 1Washington University Orthopedics, Barnes Jewish Hospital, 660 S. Euclid Avenue, Campus Box 8233, St. Louis, MO 63110, USA.

The Bone & Joint Journal
|January 3, 2017
PubMed
Summary

Obesity is linked to younger patients needing total hip arthroplasty (THA) and a higher risk of complications. More research is needed to understand obesity

Keywords:
ComplicationsEconomic burdenObesityOutcomesTotal hip arthroplasty

More Related Videos

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

3.7K
The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report
07:45

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

3.9K

Related Experiment Videos

Last Updated: Mar 9, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

3.7K
The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

3.7K
The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report
07:45

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

3.9K

Area of Science:

  • Orthopedic Surgery
  • Obesity Research
  • Biomedical Engineering

Background:

  • Obesity is a growing public health concern with potential implications for surgical outcomes.
  • Total hip arthroplasty (THA) is a common procedure to treat hip arthritis.
  • Understanding the impact of obesity on THA is crucial for patient selection and management.

Purpose of the Study:

  • To systematically review current scientific evidence on the effects of obesity on total hip arthroplasty (THA).
  • To investigate obesity's influence on the timing of THA, complication rates, and clinical/functional outcomes.

Main Methods:

  • A systematic review adhering to PRISMA guidelines.
  • Searched PubMed/Medline, Embase, and Cochrane Library for prospective studies on primary THA in obese patients (BMI ≥ 30 kg/m²).
  • Included 17 articles representing 13,722 THA patients.

Main Results:

  • Obesity was associated with a younger age at the time of primary THA compared to non-obese individuals.
  • Obese patients experienced a significantly increased incidence of complications, up to four-fold.
  • The effect of obesity on clinical and functional outcomes of primary THA was mixed; three studies indicated a detrimental effect, while eight showed no significant impact.

Conclusions:

  • Obesity is associated with earlier THA and a higher likelihood of peri-operative complications.
  • Further research is warranted to clarify the impact of obesity on clinical outcomes due to conflicting current literature.
  • This review highlights the need for careful consideration of obesity in THA planning and management.