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Platelets miRNA as a Prediction Marker of Thrombotic Episodes
Michal Bijak1, Malgorzata Dzieciol2, Joanna Rywaniak1
1Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Abstract:
The blood platelets are crucial for the coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. The studies of recent years have shown that anucleated platelets are able to succeed protein synthesis. Additionally, mRNA translation in blood platelets is regulated by miRNA molecules. Recent works postulate the possibility of using miRNAs as biomarkers of atherosclerosis and ischemic episodes. This review article describes clinical studies that presented blood platelets miRNAs expression profile changes in different thrombotic states, which suggest use of these molecules as predictive biomarkers.
Insights
Blood platelets, crucial for hemostasis, can synthesize proteins and are regulated by microRNAs (miRNAs). Changes in platelet miRNA expression may serve as predictive biomarkers for thrombotic states like atherosclerosis.
Area of Science:
- Hematology
- Molecular Biology
- Biomarker Discovery
Background:
- Blood platelets are vital for hemostasis and implicated in pathologies like atherosclerosis and thrombosis.
- Recent findings indicate that anucleated platelets can perform protein synthesis.
- MicroRNA (miRNA) molecules regulate mRNA translation within blood platelets.
Purpose of the Study:
- To review clinical studies examining blood platelet miRNA expression profiles in thrombotic states.
- To explore the potential of miRNAs as predictive biomarkers for atherosclerosis and ischemic events.
Main Methods:
- Literature review of clinical studies.
- Analysis of miRNA expression profiles in blood platelets from patients with thrombotic conditions.
Main Results:
- Significant alterations in blood platelet miRNA expression patterns are observed in various thrombotic states.
- These expression changes suggest a role for miRNAs in the pathophysiology of thrombosis and atherosclerosis.
Conclusions:
- Blood platelet miRNAs show promise as predictive biomarkers for thrombotic conditions.
- Further research into miRNA profiles could enhance early detection and risk assessment for atherosclerosis and ischemic episodes.
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