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Updated: Aug 12, 2026
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Murine Flexor Tendon Injury and Repair Surgery
Published on: September 19, 2016
13.8K
Cell and Biologic-Based Treatment of Flexor Tendon Injuries
Stephen W Linderman1, Richard H Gelberman2, Stavros Thomopoulos3
1Department of Orthopaedic Surgery, Washington University, St. Louis, MO, United States; Department of Biomedical Engineering, Washington University, St. Louis, MO, United States.
Operative Techniques in Orthopaedics
|January 3, 2017
Summary
New biologic therapies using growth factors and mesenchymal stem cells (MSCs) show promise for improving flexor tendon repair outcomes by enhancing strength and preventing adhesions.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Orthopedic Surgery
Background:
- Intrasynovial flexor tendon repair often results in poor outcomes due to adhesion formation and repair site failure.
- Current multi-strand repair and rehabilitation techniques yield unsatisfactory results, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review recent advancements in cell and biologic-based experimental treatments for flexor tendon injuries.
- To highlight the potential of growth factors and mesenchymal stem cells (MSCs) in improving tendon repair.
Main Methods:
- Summary of current literature on cell and biologic-based therapies for flexor tendon repair.
- Emphasis on translational studies using large animal models.
- Focus on spatiotemporal delivery of cells, growth factors, and scaffolds.
Main Results:
- Biological therapies aim to simultaneously promote matrix synthesis for increased biomechanical strength and suppress adhesions.
- Mesenchymal stem cells (MSCs) and growth factors are key components in these advanced treatment strategies.
- Controlled delivery systems are crucial for successful therapeutic outcomes.
Conclusions:
- Cell and biologic-based therapies offer a promising alternative to conventional methods for flexor tendon repair.
- Future research should focus on optimizing the delivery and efficacy of these regenerative approaches.
- Large animal studies are vital for translating these experimental treatments into clinical practice.
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