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Nutrigenomic Functions of PPARs in Obesogenic Environments
Soonkyu Chung1, Young Jun Kim2, Soo Jin Yang3
1Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
Peroxisome proliferator-activated receptors (PPARs) regulate adipocyte development and metabolism. Understanding PPARs
Area of Science:
- Molecular biology
- Metabolic research
- Nutritional science
Background:
- Peroxisome proliferator-activated receptors (PPARs) are key transcription factors in metabolic regulation.
- PPARs mediate nutrient and drug effects in obesogenic environments, influencing gene expression.
Approach:
- This review synthesizes current knowledge on PPARs' roles in adipocyte differentiation.
- It examines interactions between dietary compounds (fatty acids, phytochemicals) and PPARs.
- The review also discusses the impact of PPAR polymorphism on obesity and metabolic health.
Key Points:
- PPARs are critical for white and brown/beige adipocyte development from progenitor cells.
- Dietary bioactive molecules modulate PPAR activity, impacting metabolic outcomes.
- PPAR genetic variations influence obesity and associated metabolic conditions.
Conclusions:
- PPARs play a vital role in modulating adiposity and metabolic adaptation to dietary and genetic factors.
- Understanding PPAR-nutrient interactions can advance individualized nutrition for obesity prevention.
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